Correspondence and papers centering on McCulloch's study of the functional organization of the central nervous system and cybernetics. McCulloch (1898-1969) was a major figure in establishing the theoretical ground for modern computers and in "biological computer" studies during the 1960s. Other topics include the brain or neural studies, biological psychiatry, chemical warfare, space biology, and U.S. Army studies. His participation in the American Society of Cybernetics and the Josiah Macy Conferences is well documented, and there are numerous papers and notes on other conferences attended.

Baruch S. Blumberg was a biomedical researcher at the Fox Chase Cancer Center, in Philadelphia, PA, during the second half of the 20th century. His research into Australia Antigen and the Hepatitis B Virus led to a vaccine for the virus and a share of the 1976 Nobel Prize in Physiology or Medicine. Dr. Blumberg also served as chief of the Geographic Medicine and Genetics Section at the NIH (1957-1964), Master of Balliol College (1989-1994), the first Director of the NASA Astrobiology Institute (1999-2002), and President of the American Philosophical Society (2005-2011).

An electrical engineer and senior editor for Aviation Week and Space Technology, Philip Klass began investigating UFOs in 1966 after participating in a panel discussion on the subject for the Institute of Electrical and Electronics Engineers (IEEE). From that time forward Klass has investigated UFO sightings in an effort to find a credible prosaic explanation, and became one of the most widely recognized UFO "debunkers." A founding member of the Committee for the Scientific Investigation of Claims of the Paranormal (CSICOP), serving on the Executive Council and the UFO subcommittee, Klass has authored seven books and numerous articles on UFOs, including the Skeptics UFO Newsletter in 1989. In the early 1970s, he became interested in space based weapons, and began collecting material related to the Strategic Defense Initiative (SDI) for a possible book. The Klass Collection relate to his forty-plus years of investigating UFO sightings, and includes correspondence with many of the leading UFOlogists, both pro and con. The collection contains case files, subject files, and correspondence. In addition, Klass' SDI material is included.